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Clinical Studies: Hypertension: In controlled clinical studies, metoprolol has been shown to be an effective antihypertensive agent when used alone or as concomitant therapy with thiazide-type diuretics, at dosages of 100 mg to 450 mg daily.
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In SPRINT, nearly 30% of the more than 9300 participants were 75 years of age or older.
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Randomization was performed through the use of a computer-generated randomization list.
The ability to block adrenaline in the heart has made metoprolol useful as an off-label treatment for some conditions not directly heart-related, such as to help people who experience certain types of anxiety disorders.
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The mechanism of the antihypertensive effects of beta-blocking agents has not been elucidated.
Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol.
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Studies have shown a true association between history of chronic kidney disease in first- or second-degree relatives, and risk of disease.
Mortality and hospitalization rates for patients with the disease are high and continue to rise.
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Recognizing that patients receiving larger chronic oral doses should not automatically be converted to a large IV dose, consideration should be given to further reducing the initial IV dose and basing subsequent doses on the clinical response (Huckleberry 2003).
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